Nutrition Market

Supplements for Tiredness: Boost Your Energy Naturally


Tiredness and fatigue are common complaints in today’s fast-paced world. While there can be many underlying causes, such as poor sleep, stress, or medical conditions, certain supplements may help alleviate symptoms of tiredness and boost energy levels. Supplements for tiredness can play a crucial role in supporting the body’s natural energy production processes and addressing nutrient deficiencies that may contribute to fatigue.

Vitamins and minerals are essential for converting food into energy, and inadequate intake can lead to tiredness and weakness. B vitamins, in particular, are vital for cellular energy production, while iron, magnesium, and vitamin D also play important roles in maintaining energy levels. Other supplements, such as ashwagandha, rhodiola, and L-theanine with caffeine, may help reduce mental and physical fatigue by enhancing the body’s resilience to stress and improving cognitive function.

This comprehensive article will explore the best supplements for tiredness, including key vitamins, minerals, and herbal extracts that have been scientifically shown to support energy levels and reduce fatigue. We will also discuss the importance of a balanced diet, regular exercise, and adequate sleep in maintaining overall energy and well-being. By understanding the role of these supplements and lifestyle factors, readers can make informed decisions about how to naturally boost their energy levels and combat tiredness.

The Role of Vitamins and Minerals in Combating Tiredness

B Vitamins: Essential for Energy Production

B vitamins play a crucial role in the body’s energy production processes. These water-soluble vitamins work together to convert food into energy, support cellular metabolism, and maintain proper nervous system function (Kennedy, 2016). Deficiencies in B vitamins can lead to symptoms of tiredness, weakness, and fatigue.

Vitamin B1 (Thiamine)

Vitamin B1, also known as thiamine, is essential for converting carbohydrates into energy. It plays a key role in the production of adenosine triphosphate (ATP), the primary energy currency of cells (Martel et al., 2022). Thiamine deficiencies can result in fatigue, weakness, and reduced cognitive function. Good dietary sources of vitamin B1 include whole grains, legumes, and fortified cereals.

Vitamin B2 (Riboflavin)

Riboflavin, or vitamin B2, is involved in various cellular processes related to energy production. It acts as a coenzyme in the electron transport chain, which is crucial for ATP synthesis (Mahabadi et al., 2022). Inadequate riboflavin intake may contribute to tiredness and impaired energy metabolism. Dairy products, eggs, and green vegetables are excellent sources of vitamin B2.

Vitamin B3 (Niacin)

Niacin, or vitamin B3, participates in numerous enzymatic reactions involved in energy production. It is a precursor to nicotinamide adenine dinucleotide (NAD) and its phosphate form (NADP), which are essential coenzymes in cellular metabolism (Kirkland & Meyer-Ficca, 2018). Niacin deficiencies can lead to fatigue, digestive issues, and neurological symptoms. Good sources include poultry, fish, nuts, and fortified grains.

Vitamin B5 (Pantothenic Acid)

Pantothenic acid, or vitamin B5, is necessary for the synthesis of coenzyme A (CoA), a key molecule in energy metabolism. CoA is involved in the breakdown of fats and carbohydrates for energy production (Trumbo, 2014). Low levels of vitamin B5 may result in fatigue and weakness. Dietary sources include meat, poultry, eggs, and whole grains.

Vitamin B6 (Pyridoxine)

Vitamin B6, or pyridoxine, is involved in numerous enzymatic reactions related to energy metabolism, neurotransmitter synthesis, and red blood cell formation (Stach et al., 2021). Deficiencies can cause tiredness, irritability, and impaired cognitive function. Good sources of vitamin B6 include poultry, fish, potatoes, and non-citrus fruits.

Vitamin B9 (Folate)

Folate, or vitamin B9, is essential for the synthesis of red blood cells, which transport oxygen throughout the body. It also plays a role in DNA synthesis and amino acid metabolism (Mahmood, 2014). Low folate levels can lead to fatigue, weakness, and megaloblastic anemia. Leafy green vegetables, legumes, and fortified grains are good sources of folate.

Vitamin B12 (Cobalamin)

Vitamin B12, or cobalamin, is crucial for red blood cell formation, neurological function, and DNA synthesis. It works closely with folate in the production of red blood cells and the metabolism of homocysteine (Green et al., 2017). Vitamin B12 deficiencies can cause fatigue, weakness, and neurological symptoms. Animal-based foods, such as meat, fish, eggs, and dairy, are the primary sources of vitamin B12. Vegans and vegetarians may require supplementation to maintain adequate levels.

Iron: Crucial for Oxygen Transport

Iron is an essential mineral that plays a vital role in the production of hemoglobin, the protein in red blood cells that carries oxygen throughout the body. Low iron levels can lead to iron-deficiency anemia, which is characterised by fatigue, weakness, and impaired cognitive function (National Institutes of Health, n.d.). Good dietary sources of iron include red meat, poultry, fish, legumes, and fortified cereals. Vegetarians and vegans may be at a higher risk of iron deficiency and may benefit from iron supplementation under medical supervision.

Magnesium: The Multitasking Mineral

Magnesium is involved in over 300 enzymatic reactions in the body, including energy production, muscle and nerve function, and blood glucose control (National Institutes of Health, n.d.). Inadequate magnesium intake can contribute to fatigue, muscle cramps, and weakness. Magnesium-rich foods include leafy green vegetables, nuts, seeds, whole grains, and legumes. Supplementation may be necessary for individuals with certain health conditions or those taking medications that interfere with magnesium absorption.

Vitamin D: The Sunshine Vitamin

Vitamin D, often referred to as the “sunshine vitamin,” is essential for calcium absorption, bone health, and immune function. It also plays a role in muscle function and mood regulation (Nair & Maseeh, 2012). Vitamin D deficiencies can manifest as persistent fatigue, muscle weakness, and mood disturbances. While sunlight exposure is the primary means of obtaining vitamin D, dietary sources include fatty fish, egg yolks, and fortified foods. Supplementation may be necessary for individuals with limited sun exposure or those at risk of deficiency.

Coenzyme Q10: Powering Cellular Energy

Coenzyme Q10 (CoQ10) is a naturally occurring compound that plays a crucial role in cellular energy production. It acts as an electron carrier in the mitochondrial electron transport chain, facilitating ATP synthesis (Hernández-Camacho et al., 2018). CoQ10 levels tend to decline with age and certain health conditions, which may contribute to fatigue and reduced energy levels. While the body can synthesise CoQ10, dietary sources include fatty fish, organ meats, and whole grains. Supplementation may be beneficial for individuals with deficiencies or increased energy demands.

Other Supplements for Tiredness and Fatigue

Ashwagandha: The Adaptogenic Herb

Ashwagandha (Withania somnifera) is an adaptogenic herb traditionally used in Ayurvedic medicine to enhance the body’s resilience to stress and improve overall well-being. Research suggests that ashwagandha may help reduce symptoms of stress, anxiety, and fatigue (Chandrasekhar et al., 2012). A randomised, double-blind, placebo-controlled study found that supplementation with a high-concentration ashwagandha root extract significantly reduced stress and anxiety levels, as well as improved sleep quality and mental alertness (Chandrasekhar et al., 2012).

Rhodiola Rosea: The Fatigue Fighter

Rhodiola rosea is an adaptogenic herb that has been used for centuries to combat fatigue, enhance physical performance, and improve mental clarity. A systematic review of randomised controlled trials concluded that rhodiola supplementation may have beneficial effects on physical and mental fatigue in various populations (Ishaque et al., 2012). The review found that rhodiola improved symptoms of fatigue, reduced perceived exertion during exercise, and enhanced cognitive function and mood (Ishaque et al., 2012).

L-Theanine and Caffeine: The Dynamic Duo

L-theanine is an amino acid found naturally in green tea that has been shown to promote relaxation and reduce stress without causing drowsiness. When combined with caffeine, L-theanine may enhance cognitive performance, improve alertness, and reduce mental fatigue (Giesbrecht et al., 2010). A study investigating the effects of L-theanine and caffeine in combination found that the supplement significantly improved attention, memory, and reaction time compared to placebo (Giesbrecht et al., 2010).

Citrulline: Boosting Nitric Oxide Production

Citrulline is a non-essential amino acid that plays a role in the production of nitric oxide, a molecule that helps dilate blood vessels and improve blood flow. Supplementation with citrulline has been shown to increase nitric oxide production, reduce fatigue, and enhance exercise performance (Gonzalez & Trexler, 2020). A review of the current literature on citrulline supplementation concluded that it may be an effective strategy to improve exercise performance and reduce fatigue, particularly in individuals with impaired nitric oxide metabolism (Gonzalez & Trexler, 2020).

Lifestyle Factors for Maintaining Energy Levels

Balanced Diet: Fuelling Your Body

Consuming a balanced diet that includes a variety of nutrient-dense foods is essential for maintaining optimal energy levels. A diet rich in whole grains, lean proteins, fruits, vegetables, and healthy fats provides the body with the necessary vitamins, minerals, and macronutrients to support energy production and overall health (Skerrett & Willett, 2010). Limiting processed and high-sugar foods can help prevent energy crashes and maintain stable blood glucose levels throughout the day.

Regular Exercise: Energising Your Mind and Body

Engaging in regular physical activity is a powerful way to boost energy levels, improve mood, and enhance overall well-being. Exercise stimulates the release of endorphins, the body’s natural mood elevators, and increases blood flow to the brain, promoting mental clarity and focus (Mikkelsen et al., 2017). Aim for at least 150 minutes of moderate-intensity aerobic exercise per week, along with strength training exercises at least twice a week (World Health Organization, 2020).

Adequate Sleep: Recharging Your Batteries

Getting enough quality sleep is crucial for maintaining energy levels, cognitive function, and overall health. Chronic sleep deprivation can lead to fatigue, irritability, and impaired performance (Medic et al., 2017). Adults should aim for 7-9 hours of sleep per night and establish a consistent sleep schedule to regulate the body’s internal clock (Watson et al., 2015). Creating a relaxing bedtime routine, avoiding electronic devices before bed, and ensuring a comfortable sleep environment can improve sleep quality and duration.

Stress Management: Preventing Burnout

Chronic stress can take a significant toll on both physical and mental energy levels, leading to fatigue, exhaustion, and burnout. Engaging in stress-reducing activities, such as meditation, deep breathing exercises, yoga, or mindfulness practices, can help alleviate stress and improve overall well-being (Sharma, 2014). Regular exercise, social support, and time management strategies can also be effective in managing stress and preventing burnout.

Consulting with a Healthcare Professional

While supplements can be a valuable tool in combating tiredness and boosting energy levels, it is essential to consult with a healthcare professional before starting any new supplement regimen. A qualified practitioner can help identify the underlying causes of fatigue, assess nutrient deficiencies, and recommend appropriate supplements based on individual needs and health status. Some supplements may interact with medications or have potential side effects, so it is crucial to seek professional guidance to ensure safety and effectiveness.


In conclusion, tiredness and fatigue are common issues that can have a significant impact on daily life and overall well-being. While there are many potential causes of tiredness, such as poor sleep, stress, or underlying health conditions, certain supplements may help alleviate symptoms and boost energy levels naturally.

Key vitamins and minerals, including B vitamins, iron, magnesium, vitamin D, and coenzyme Q10, play crucial roles in the body’s energy production processes. Deficiencies in these nutrients can contribute to feelings of tiredness, weakness, and fatigue. Incorporating a balanced diet rich in whole grains, lean proteins, fruits, and vegetables can help ensure an adequate intake of these essential nutrients. Other supplements, such as ashwagandha, rhodiola, L-theanine with caffeine, and citrulline, have shown promise in reducing mental and physical fatigue, enhancing cognitive function, and improving exercise performance.

However, it is essential to remember that supplements should not be relied upon as a sole solution for tiredness. Lifestyle factors, such as regular exercise, adequate sleep, and effective stress management techniques, are equally important in maintaining optimal energy levels and overall health. Before starting any new supplement regimen, it is crucial to consult with a healthcare professional to discuss individual needs, potential interactions with medications, and possible side effects. By taking a holistic approach that combines targeted supplementation with healthy lifestyle habits, individuals can effectively combat tiredness and improve their energy levels, ultimately enhancing their quality of life.

Key Highlights and Actionable Tips

  • Feeling tired all the time is a common problem in today’s fast-paced world. It’s important to pay attention to your diet and ensure you’re getting enough key energy nutrients.
  • Energy is something your body makes from the food you eat, with the help of tiny compounds called micronutrients. A balanced diet from natural whole foods should supply all the micronutrients you need.
  • The top 5 vitamins for energy are: B1 (thiamin), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), and B6 (pyridoxine). These vitamins are essential for converting food into energy.
  • The best food sources of these energy vitamins include: pork, fish, nuts, seeds, eggs, dairy, spinach, avocado, mushrooms, tuna, chicken, turkey, salmon, beef, sweet potatoes, and lentils.
  • Optimising key energy nutrients in your diet is a great way to support your energy levels. Familiarise yourself with the top energy vitamins and which foods you’ll find them in.

What other lifestyle factors can impact energy levels besides diet?

Aside from diet, several other lifestyle factors can significantly impact energy levels. These include:

  • Sleep: Getting enough quality sleep is crucial for maintaining energy throughout the day. Aim for 7-9 hours per night and establish a consistent sleep routine.
  • Stress management: Chronic stress can be exhausting and drain your energy. Engage in stress-reducing activities like meditation, deep breathing, or yoga.
  • Exercise: Regular physical activity can actually boost energy levels by improving cardiovascular health and increasing endorphins. Aim for at least 30 minutes of moderate exercise most days of the week.
  • Hydration: Even mild dehydration can cause fatigue. Make sure to drink plenty of water throughout the day, especially if you’re exercising or in a hot environment.
  • Limiting alcohol and caffeine: While a cup of coffee can provide a temporary energy boost, relying on caffeine too much can lead to crashes. Similarly, alcohol can interfere with sleep quality and contribute to fatigue.

Can vitamin deficiencies cause other symptoms besides fatigue?

Yes, vitamin deficiencies can cause a wide range of symptoms beyond just fatigue. Some examples include:

  • Vitamin B12 deficiency: In addition to fatigue, vitamin B12 deficiency can cause weakness, constipation, nerve problems, and mental health issues like depression and confusion.
  • Vitamin D deficiency: Low vitamin D levels have been linked to bone pain, muscle weakness, and increased risk of infections.
  • Vitamin C deficiency: Also known as scurvy, severe vitamin C deficiency can cause symptoms like bleeding gums, poor wound healing, and joint pain.
  • Vitamin A deficiency: Inadequate vitamin A intake can lead to vision problems, dry skin, and weakened immune function.
  • Vitamin K deficiency: While rare, vitamin K deficiency can cause bleeding and bruising easily.

If you suspect you may have a vitamin deficiency, it’s important to speak with your healthcare provider for proper testing and treatment.

Are there any risks associated with taking vitamin supplements for energy?

While vitamin supplements can be helpful for correcting deficiencies and supporting energy levels, there are some potential risks to be aware of:

  • Interactions with medications: Some vitamins can interact with certain medications, such as vitamin K interfering with blood thinners. Always check with your doctor before starting supplements if you take any medications.
  • Overdose: It’s possible to consume too much of certain vitamins, particularly fat-soluble ones like vitamins A, D, E, and K. Stick to the recommended dosages to avoid potential toxicity.
  • Quality and purity: Supplements are not as strictly regulated as medications. Look for brands that have been independently tested for quality and purity by organisations like ConsumerLab or USP.
  • Masking underlying health issues: While supplements can help with symptoms like fatigue, they shouldn’t be used as a substitute for addressing underlying health problems. If your fatigue persists despite a balanced diet and lifestyle, see your healthcare provider to rule out any medical conditions.

As with any supplement regimen, it’s always best to consult with a qualified healthcare professional for personalised advice.

How long does it typically take to notice improvements in energy levels after making dietary changes?

The time it takes to notice improvements in energy levels after making dietary changes can vary from person to person. Some factors that can influence this include:

  • The extent of the deficiency: If you have a severe vitamin deficiency, it may take longer to replenish your body’s stores and notice a difference in energy levels.
  • Consistency: Eating a balanced, nutrient-rich diet consistently over time is key. You may not notice dramatic changes overnight, but sticking with healthy habits should lead to improvements within a few weeks to a month.
  • Individual metabolism: Some people may naturally have faster or slower metabolisms, which can affect how quickly they process and absorb nutrients.
  • Other lifestyle factors: As mentioned earlier, diet is just one piece of the puzzle. Factors like sleep, stress, and exercise can also impact energy levels and may need to be addressed simultaneously.

In general, most people should start to notice positive changes in energy within a few weeks of consistently eating a balanced, whole-food diet that includes a variety of energy-supporting vitamins and minerals. However, if fatigue persists or worsens despite dietary changes, it’s important to consult with a healthcare provider to rule out any underlying medical conditions.

Can you get enough of these energy vitamins from diet alone, or are supplements necessary?

In theory, it’s possible to get enough of these energy vitamins from diet alone if you’re eating a balanced, varied diet that includes plenty of whole foods. However, there are some situations where supplements may be necessary or beneficial:

  • Restricted diets: If you follow a restricted diet, such as veganism or a very low-calorie diet, you may be at higher risk for certain vitamin deficiencies. For example, vitamin B12 is primarily found in animal products, so vegans may need to supplement or eat fortified foods.
  • Poor absorption: Some people may have conditions that interfere with their ability to properly absorb vitamins from food, such as inflammatory bowel disease or celiac disease. In these cases, supplements may be necessary to ensure adequate intake.
  • Pregnancy: Pregnant women have increased nutrient needs to support fetal development. Prenatal vitamins are often recommended to ensure adequate intake of key vitamins like folic acid and iron.
  • Older adults: As we age, our ability to absorb and utilise certain vitamins may decline. Older adults may benefit from supplements of vitamins B12, D, and others.
  • Picky eaters: Children or adults who are very picky eaters may not consume a wide enough variety of foods to meet their vitamin needs.

That being said, it’s always best to aim to meet your nutrient needs through a balanced diet first and foremost. If you do choose to take supplements, be sure to choose high-quality products and talk to your healthcare provider to ensure they’re safe and appropriate for your individual needs.


Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262.

Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 13(6), 283–290.

Gonzalez, A. M., & Trexler, E. T. (2020). Effects of citrulline supplementation on exercise performance in humans: A review of the current literature. Journal of Strength and Conditioning Research, 34(5), 1480–1495.

Hernández-Camacho, J. D., Bernier, M., López-Lluch, G., & Navas, P. (2018). Coenzyme Q10 supplementation in aging and disease. Frontiers in Physiology, 9, 44.

Ishaque, S., Shamseer, L., Bukutu, C., & Vohra, S. (2012). Rhodiola rosea for physical and mental fatigue: A systematic review. BMC Complementary and Alternative Medicine, 12, 70.

Kirkland, J. B., & Meyer-Ficca, M. L. (2018). Niacin. Advances in Food and Nutrition Research, 83, 83–149.

Mahabadi, N., Bhusal, A., & Banks, S. W. (2022). Riboflavin deficiency. In StatPearls. StatPearls Publishing.

Martel, J. L., Kerndt, C. C., & Franklin, D. S. (2022). Vitamin B1 (thiamine). In StatPearls. StatPearls Publishing.

Nair, R., & Maseeh, A. (2012). Vitamin D: The “sunshine” vitamin. Journal of Pharmacology & Pharmacotherapeutics, 3(2), 118–126.

Stach, K., Stach, W., & Augoff, K. (2021). Vitamin B6 in health and disease. Nutrients, 13(9), 3229.

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