Activated Folate

Activated Folate

Activated folate, also known as L-methylfolate or 5-MTHF, is the naturally occurring and most bioavailable form of vitamin B9 (folate). The products contain activated folate rather than folic acid. This page outlines the key differences between activated folate and folic acid and why the products use the activated form.

Why the Products Use Activated Folate Instead of Folic Acid

Folic acid is the synthetic form of folate used to fortify foods and found in most supplements. While folic acid is effective at preventing folate deficiency, research shows up to 60% of people have difficulty properly converting folic acid into its active form due to common genetic mutations. This can limit its effectiveness and potentially lead to unmetabolised folic acid building up in the blood.

Activated folate, on the other hand, is the bioidentical form found naturally in foods such as leafy greens. It does not require any conversion to become metabolically active in the body. Studies show activated folate is up to seven times more bioavailable than folic acid.

By using activated folate in the products, it ensures maximum absorption and utilisation to support optimal health. The activated folate is ideal if customers have:

• Struggled with fertility or recurrent pregnancy loss
• Impaired ability to process folic acid
• Had a slow response to folic acid supplementation
• Are over the age of 50 - absorption decreases with age

Key Benefits of Activated Folate

Activated folate offers all the benefits of folic acid along with improved bioavailability and tolerance.

1. Supports Healthy Pregnancy

Folate is essential before and during early pregnancy to prevent neural tube defects and support the developing foetus. As activated folate does not require conversion, it is the optimal form to ensure adequate folate status during this critical growth phase.

2. Maintains Homocysteine Levels

Elevated homocysteine is an independent risk factor for cardiovascular disease. Activated folate plays a key role in homocysteine metabolism and recycling back into methionine or cysteine amino acids. This helps keep levels within a healthy range.

3. Promotes Normal Mood and Motivation

Folate is required for the production of serotonin, dopamine and norepinephrine - the ‘happy hormones’. Along with vitamin B12, activated folate supports neurotransmitter regulation and defence against depressive symptoms.

4. Supports Brain Health and Cognitive Function

Higher blood folate levels are associated with better cognitive performance and protection against age-related cognitive decline. Activated folate supports brain health by maintaining nerve integrity and promoting regeneration capacities.

5. Boosts Cellular Health and Longevity

Activated folate has antioxidant properties that help reduce oxidative damage to cells and tissue caused by free radicals. This supports longevity by maintaining the integrity of DNA structure.

Frequently Asked Questions

Is activated folate just a fancy name for folic acid?

No. While activated folate and folic acid are both forms of vitamin B9, they have distinct chemical structures. Folic acid is the synthetic version used in supplements and food fortification. Activated folate is the naturally occurring, bioidentical form found in foods.

Why should customers take an activated folate supplement?

Taking an activated folate supplement is most beneficial for people who have a genetic mutation that impairs folic acid metabolism, including up to 60% of the population. An activated folate supplement ensures optimal absorption and bioavailability without the possible side effects or health risks associated with unmetabolised folic acid build-up over time.

How is activated folate different from regular folate?

Activated folate, also labeled as L-methylfolate or 5-MTHF, is the most biologically active form of folate. Regular folic acid needs to be converted in the body through a series of enzymatic processes before it can be utilised. Up to 60% of people have genetic defects in one or more of these enzymes, limiting folic acid metabolism and activity.

When is the best time to take activated folate supplements?

The best time is first thing in the morning with or without food. Activated folate absorption occurs primarily in the small intestine and can compete with other folate forms for transport across intestinal cells. Taking it on an empty stomach when intestinal transit time is slower allows for optimal contact time and absorption.

Are there any side effects from taking activated folate?

Activated folate is extremely well tolerated with no commonly reported side effects when taken at recommended dosages. As it is the natural form found in the diet, risks associated with excess folic acid intake do not apply to activated folate supplementation under supervision of a healthcare provider.

Who should not take activated folate?

The only precautions for activated folate use are if customers have pernicious anaemia or are allergic to folate compounds. Those on anti-epileptic medications should consult their doctor before taking activated folate, as it may interact with the medication’s absorption and clearance.